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M94A2591.TXT
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1994-10-25
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Document 2591
DOCN M94A2591
TI A comparison of cervical abnormalities in HIV infected and uninfected
pregnant women.
DT 9412
AU Connor J; Mitchell JL; Lockhart M; Loftman PO; Carrington B; Matseaone
S; Harlem Hospital Center, New York.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):27 (abstract no. 080B). Unique
Identifier : AIDSLINE ICA10/94369984
AB OBJECTIVE: To compare the rates and severity of cervical abnormalities
of HIV infected and uninfected women seen in a prenatal clinic for drug
users controlling for age, parity, history of STD'S, Human papilloma
virus, and type and route of drug use. METHODS: Charts of women who
received care in a special prenatal clinic for drug abusers (N = 1300)
were reviewed for PAP smear results, history and current STD status,
age, parity, drug use. HIV infected women were divided into 3 groups-CD4
counts > 500, CD4 counts between 500 & 200, and CD4 counts < 200 and
matched to HIV uninfected women with similar characteristics. RESULTS:
The HIV infection rate for the clinic is 20%. Cervical abnormalities
were found in 33% of the total uninfected group but in 63% of the
infected group. In the HIV infected group with abnormalities, 16% had
evidence of HPV infection, compared to 6% of the uninfected group.
However, preliminary analyses of the first 210 matched pairs suggest
that the HIV infected group with CD4 > 500 had rates of abnormalities
(36%) comparable to the uninfected group. The group with CD4 500-200 had
a rates of approx. 46%. The group with CD4 < 200 had rates of 96% and
the severest abnormalities. In the CD4 > 500, heroin and age > 30 was
associated with abnormalities more than non-heroin use and age < 30.
DISCUSSION AND CONCLUSION: Most studies of cervical abnormalities in HIV
infected women have not used as a comparison a group of women match for
similar characteristics but not HIV infected. Many of these
characteristics increases the risk of cervical abnormalities without HIV
infection. Better understanding of the impact of these characteristics
is needed.
DE Age Factors Cervix Diseases/MICROBIOLOGY/*PATHOLOGY Female Heroin
Dependence/COMPLICATIONS Human HIV Infections/*PATHOLOGY Leukocyte
Count Papillomavirus, Human/ISOLATION & PURIF Papovaviridae
Infections/MICROBIOLOGY Pregnancy Pregnancy Complications,
Infectious/*PATHOLOGY Tumor Virus Infections/MICROBIOLOGY T4
Lymphocytes *Vaginal Smears MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).